GABAa receptor is a ligand-gated ion channel (also known as ionotropic receptor) which responds to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). The ionotropic GABAa receptor has influence on multiple neural functions and is also the molecular target of the benzodiazepine class of tranquilizer drugs.

Fig. 1 H₂O₂ regulates the voltage sensitivity of the tonic GABA current

Here in Creative Bioarray, we provide target screening on a series of GABAa channels listed as below:

GABAa (α1/β2/γ2) (GABRA1/GABRB2/GABRG2)

Disease: mutations in GABRA1 have been linked to familial juvenile myoclonic epilepsy.

Therapeutic Targets: seizures and anxiety.

GABAa (α1β3γ2) (GABRA1/GABRB3/GABRG2)

Therapeutic Targets: epilepsy and other neurological disorders.

GABAa(α2β2γ2) (GABRA2/GABRB2/GABRG2)

Therapeutic Targets: neurological and psychological disorders (e.g., seizure and anxiety).

GABAa (α3β2γ2) (GABRA3/GABRB2/GABRG2)

Therapeutic Targets: seizures, anxiety and other neurological disorders.

GABAa (α4β3d) (GABRA4/GABRB3/GABRD)

Therapeutic Targets: seizures.

GABAa (α5β2γ2) (GABRA5/GABRB2/GABRG2)

Therapeutic Targets: neurological and psychological disorders (e.g., cognitive impairment and schizophrenia).

Reference

1. Penna A, et al. Hydrogen Peroxide Increases GABAA Receptor-Mediated Tonic Current in Hippocampal Neurons. J Neurosci. 2014; 34: 10624–10634.

Related Section

• Sodium Channels
• Calcium Channels
• Potassium Channels
• Chloride Channels
• TRP Channels
• ATP gated P2X Channels
• ASICs
• Nicotinic Acetylcholine Receptors
• Ionotropic Glutamate-gated Receptors
• Glycine Receptors
• 5-HT Receptors3
• Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)
• Other Ion Channels