Extracellular adenosine mediates a multitude of biological effects, including wakefulness, antiarrythmia, bronchoconstriction and response to ischemia and oxidative stress. A family of four G protein-coupled adenosine receptors, A1, A2A, A2B and A3, is responsible for these effects. A2A, which couples to Gs, is expressed in basal ganglia and immune cells. A2A reduces ischemia-induced inflammation; however, A2A antagonists protect from neurodegeneration during Parkinson"s disease. Caffeine, the most widely used psychoactive drug, is a nonselective adenosine receptor antagonist, but its psychomotor stimulant affect is attributed to A2A expressed on striatal projection neurons.
Product Information | |
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Catalog #: | ACC-RG0601 |
Gene Name | ADORA2A |
Abbr | HEK293-HuADORA2A/Clytin |
Alias | ADORA2A,RDC8,hA2aR |
Growth Properties | Adherent |
Host Cell | HEK293 |
Morphology | Epithelial |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | ADORA2A,RDC8,hA2aR |
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