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Human ASIC3 Stable Cell Line-HEK293

Acid-sensing ion channels (ASICs) are structurally related to epithelial sodium channel proteins. They are gated by protons, blocked by amiloride, and their transcripts are localized to sensory ganglia. Their pH sensitivity and distribution makes them interesting candidates to serve as primary transducers of local pH changes during ischemia or tissue injury to pain signals to the CNS. These channels can allow quite large and persistent inward currents in native sensory neurons that can cause sustained firing of action potentials that lead to pain perception. Using the rat ASIC3 sequence de Weille et al. cloned the human gene encoding ASIC3. During severe cardiac ischemia extracellular pH levels can drop as low as 6.7, and a study of eight different functional properties of large acid-gated currents in rat cardiac afferent neurons corresponded well to ASIC3 channels transfected into COS-7 cells.

Product Information
Catalog #:  ACC-RI0015
Gene Name:  ASIC3
Abbr HEK293-HuASIC3
Alias ASIC3,ACCN3,DRASIC,SLNAC1,TNaC1
Channel Type Acid-sensing Ion Channel
Growth Properties Adherent
Host Cell HEK293
Morphology Epithelial
Product Format frozen
Product Type Ion Channel Expressing Cell
searchKeyword ASIC3,ACCN3,DRASIC,SLNAC1,TNaC1
Shipping Dry ice
Species Human

Related Products

Catalog Product Name Gene Name Species Morphology Price
ACC-RI0065 Human ACCN3 Stable Cell Line-CHO ASIC3 Human Epithelial-like INQUIRY
Our products are only for research use. Not intended for any clinical or diagnostic use.

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