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- Human AVPR2 Stable Cell Line - CHO-K1/Gα15
Human AVPR2 Stable Cell Line - CHO-K1/Gα15
AVPR2 (Arginine Vasopressin Receptor 2) is a Protein Coding gene. Diseases associated with AVPR2 include Nephrogenic Syndrome Of Inappropriate Antidiuresis and Diabetes Insipidus, Nephrogenic, X-Linked. Among its related pathways are Vesicle-mediated transport and Clathrin-mediated endocytosis. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and vasopressin receptor activity. An important paralog of this gene is AVPR1B. This gene encodes the vasopressin receptor, type 2, also known as the V2 receptor, which belongs to the seven-transmembrane-domain G protein-coupled receptor (GPCR) superfamily, and couples to Gs thus stimulating adenylate cyclase. The subfamily that includes the V2 receptor, the V1a and V1b vasopressin receptors, the oxytocin receptor, and isotocin and mesotocin receptors in non-mammals, is well conserved, though several members signal via other G proteins. All bind similar cyclic nonapeptide hormones. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. The V2 receptor is also expressed outside the kidney although its tissue localization is uncertain. When these 'extrarenal receptors' are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known - its absence does not appear to be detrimental in NDI patients. The gene expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing.
| Product Information | |
|---|---|
| Catalog #: | ACC-RG1773 |
| Gene Name | AVPR2 |
| Abbr | AVPR2 |
| Alias | AVPR2 |
| Host Cell | CHO-K1/Gα15 |
| Shipping | Dry ice |
| Product Type | GPCR Expressing Cell |
| Species | Human |
| Product Format | Liquid nitrogen |
| searchKeyword | AVPR2 |
Related Products
| Catalog | Product Name | Gene Name | Species | Morphology | Price |
|---|---|---|---|---|---|
| ACC-RG0939 | Human AVPR2 Stable Cell Line-CHO | AVPR2 | Human | Epithelial-like | INQUIRY |
| ACC-RG1228 | Human AVPR2 Validated Stable Cell Line-1321N1 | AVPR2 | Human | Glial | INQUIRY |
| ACC-RG0057 | Human AVPR2-SNAP Stable Cell Line-HEK293 | AVPR2 | Human | Epithelial | INQUIRY |
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