Arginine vasopressin (AVP) is a 9 amino acid peptide that functions as an antidiuretic, vasoconstrictor and neurotransmitter. The three vasopressin receptors, V1a, V1b and V2, are GPCRs; V1a and V1b couple to Gq and calcium release, whereas V2 couples to Gs. V2 expressed in renal collecting ducts plays an important role in regulating renal free water excretion. Mutations in V2 result in X-linked nephrogenic diabetes insipidus, a syndrome in which the kidney is unable to concentrate urine, leading to dehydration and hypernatremia. Conversely, elevated levels of AVP lead to hyponatremia in the syndrome of inappropriate antidiuretic hormone secretion (SIADH), congestive heart failure or cirrhosis, and V2 selective antagonists have been developed to treat these conditions.

Product Information
Catalog #:	ACC-RG1228
Gene Name	AVPR2
Abbr	1321N1-HuAVPR2 Validated
Alias	AVPR2,DIR,DIR3,V2R,DI1,DIR,NDI,ADHR,DIR3,MGC126533,MGC138386
Growth Properties	Adherent
Host Cell	1321N1
Morphology	Glial
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	AVPR2,DIR,DIR3,V2R,DI1,DIR,NDI,ADHR,DIR3,MGC126533,MGC138386

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