Human CHRNA7 Stable Cell Line-HEK293

alpha7 nicotinic acetylcholine (nACh7) receptors are predominantly expressed in the CNS, including the hippocampus, cortex and ventral tegmental area. Nicotinic ACh7 receptors are involved with LTP, memory and attention deficits and so are drug development targets for diseases of cognition including Alzheimer's and schizophrenia. The nACh7 receptors are rapidly desensitized, have homopentameric architecture and respond to agonists including nicotine, acetylcholine, AR-R17779 and epibatidine. In addition the currents are blocked by the competitive antagonist methyllycaconitine. Drug discovery efforts have also identified positive allosteric modulators such as PNU-120596 which increase the potency of activators such as acetylcholine without causing desensitization. This cell line also expresses the ric3 chaperone protein as when co-expressed with the nACh7 receptor, ric-3 significantly increases surface expression.

Product Information
Catalog #:	ACC-RI0020
Gene Name	CHRNA7
Abbr	HEK293-HuCHRNA7
Alias	CHRNA7,NACHRA7,CHRNA7-2
Growth Properties	Adherent
Host Cell	HEK293
Morphology	Epithelial
Shipping	Dry ice
Product Type	Ion Channel Expressing Cell
Channel Type	Ligand-gated Ion Channel
Channel Subgroup	Acetylcholine Receptor
Species	Human
Product Format	frozen
searchKeyword	CHRNA7,NACHRA7,CHRNA7-2