CX3CR1 is a GPCR expressed on natural killer cells, cytotoxic T lymphocytes, and macrophages. The sole ligand for CX3CR1, fractalkine, is an unusual chemokine that is expressed as a transmembrane molecule with a CX3C domain and a mucin domain. Fractalkine is highly expressed on endothelial cells activated by TNFalpha and other proinflammatory cytokines, and fractalkine/CX3CR1 interactions mediate recruitment of macrophages into the atherosclerotic plaque. In addition, fractalkine and CX3CR1 have been implicated in the pathogenesis of glomerulonephritis, HIV infection and rheumatoid arthritis.

Product Information
Catalog #:	ACC-RG1144
Gene Name	CX3CR1
Abbr	CHO-HuCX3CR1 Validated
Alias	CX3CR1,CMKBRL1,GPR13,CCRL1,CMKDR1,V28,CMK-BRL1,CMK-BRL-1,C-X3-C CKR-1,GPR13,GPRV28,CMKBRL1
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	CX3CR1,CMKBRL1,GPR13,CCRL1,CMKDR1,V28,CMK-BRL1,CMK-BRL-1,C-X3-C CKR-1,GPR13,GPRV28,CMKBRL1

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