The GPCR CXCR6 (previously known as BONZO, STRL33 and TYMSTR) binds selectively to the free chemokine domain of CXCL16, which is derived from a membrane-bound precursor containing a CXC-containing chemokine domain, a glycosylated mucin-like domain, and a transmembrane domain. CXCR6 is selectively expressed on Th1, Th2 and Tr1 T cell subsets, whereas CXCL16 is expressed on monocytes/macrophages and dendritic cells. CXCR6 functions as a cofactor with CD4 for HIV entry and Env-mediated cell fusion. Binding of CXCL16 to CXCR6 promotes migration of activated lymphocytes to sites of inflammation in tissues such as liver and synovium.
| Product Information | |
|---|---|
| Catalog #: | ACC-RG1147 | 
| Gene Name: | CXCR6 | 
| Abbr | CHO-HuCXCR6 Validated | 
| Alias | CXCR6,BONZO,CD186,STRL33,TYMSTR,CDw186,CXC-R6,CXCR-6 | 
| Growth Properties | Adherent | 
| Host Cell | CHO-K1 | 
| Morphology | Epithelial-like | 
| Product Format | frozen | 
| Product Type | GPCR Expressing Cell | 
| searchKeyword | CXCR6,BONZO,CD186,STRL33,TYMSTR,CDw186,CXC-R6,CXCR-6 | 
| Shipping | Dry ice | 
| Species | Human | 
Related Products
| Catalog | Product Name | Gene Name | Species | Morphology | Price | 
|---|---|---|---|---|---|
| ACC-RG1727 | Human CXCR6 Stable Cell Line-HEK293T Gαqi5 | CXCR6 | Human | INQUIRY | 
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