The GPCR CXCR6 (previously known as BONZO, STRL33 and TYMSTR) binds selectively to the free chemokine domain of CXCL16, which is derived from a membrane-bound precursor containing a CXC-containing chemokine domain, a glycosylated mucin-like domain, and a transmembrane domain. CXCR6 is selectively expressed on Th1, Th2 and Tr1 T cell subsets, whereas CXCL16 is expressed on monocytes/macrophages and dendritic cells. CXCR6 functions as a cofactor with CD4 for HIV entry and Env-mediated cell fusion. Binding of CXCL16 to CXCR6 promotes migration of activated lymphocytes to sites of inflammation in tissues such as liver and synovium.

Product Information
Catalog #:	ACC-RG1147
Gene Name	CXCR6
Abbr	CHO-HuCXCR6 Validated
Alias	CXCR6,BONZO,CD186,STRL33,TYMSTR,CDw186,CXC-R6,CXCR-6
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	CXCR6,BONZO,CD186,STRL33,TYMSTR,CDw186,CXC-R6,CXCR-6

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