The GPCR CXCR6 (previously known as BONZO, STRL33 and TYMSTR) binds selectively to the free chemokine domain of CXCL16, which is derived from a membrane-bound precursor containing a CXC-containing chemokine domain, a glycosylated mucin-like domain, and a transmembrane domain. CXCR6 is selectively expressed on Th1, Th2 and Tr1 T cell subsets, whereas CXCL16 is expressed on monocytes/macrophages and dendritic cells. CXCR6 functions as a cofactor with CD4 for HIV entry and Env-mediated cell fusion. Binding of CXCL16 to CXCR6 promotes migration of activated lymphocytes to sites of inflammation in tissues such as liver and synovium.
| Product Information | |
|---|---|
| Catalog #: | ACC-RG1147 |
| Gene Name: | CXCR6 |
| Abbr | CHO-HuCXCR6 Validated |
| Alias | CXCR6,BONZO,CD186,STRL33,TYMSTR,CDw186,CXC-R6,CXCR-6 |
| Growth Properties | Adherent |
| Host Cell | CHO-K1 |
| Morphology | Epithelial-like |
| Product Format | frozen |
| Product Type | GPCR Expressing Cell |
| searchKeyword | CXCR6,BONZO,CD186,STRL33,TYMSTR,CDw186,CXC-R6,CXCR-6 |
| Shipping | Dry ice |
| Species | Human |
Related Products
| Catalog | Product Name | Gene Name | Species | Morphology | Price |
|---|---|---|---|---|---|
| ACC-RG1727 | Human CXCR6 Stable Cell Line-HEK293T Gαqi5 | CXCR6 | Human | INQUIRY |
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