Endothelins are a family of vasoactive peptides that include ET-1, ET-2 and ET-3. To date, two subtype of endothelin receptors have been identified from mammalian cells, EDNRA (ETA) and EDNRB (ETB). The EDNRA receptors (ETA) have a much greater affinity for ET-1 over ET-3 and are expressed abundantly in vascular smooth muscles and stromal tissues. The vasoconstrictor and proliferative effects of ET-1 are primarily mediated by the EDNRA receptor. This makes EDNRA a good target for drug development in a number of cardiovascular diseases, including congestive heart failure, hypertension, stroke, kidney failure, and a variety of non-cardiovascular conditions, such as asthma, chronic obstructive pulmonary disease, pain and cancer.

Product Information
Catalog #:	ACC-RG0838
Gene Name	EDNRA
Abbr	CHO-HuEDNRA
Alias	EDNRA,ETA,ET-A,ETAR,ETRA,ETA-R,hET-AR
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Stability	12 passages of continuous culture (6 weeks) at 2 passages/week
Product Format	frozen
searchKeyword	EDNRA,ETA,ET-A,ETAR,ETRA,ETA-R,hET-AR

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