Protease-activated receptor-2 (PAR2) belongs to a four-member family of GPCRs that are activated by proteases (see Ossovskaya et al for review). These proteases cleave a specific extracellular amino-terminal domain of the receptor to reveal a tethered ligand, which in turn activates the receptor which couples via Gq to release intracellular calcium (Nystedt, S. et al., 1995). PAR2 is expressed in the vasculature, GI tract, CNS, lung, kidney, liver, and heart. PAR2 is a relevant target for arthritis, inflammation, bowel disease, and cancer.
Product Information | |
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Catalog #: | ACC-RG0920 |
Gene Name | F2RL1 |
Abbr | CHO-HuF2RL1 |
Alias | F2RL1,GPR11,PAR2,PAR-2 |
Growth Properties | Adherent |
Host Cell | CHO-K1 |
Morphology | Epithelial-like |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Stability | 12 passages (6 weeks of continuous culture) |
Product Format | frozen |
searchKeyword | F2RL1,GPR11,PAR2,PAR-2 |
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