Protease-activated receptor-4 (PAR4) belongs to a four-member family of GPCRs that are activated by proteases (see Ossovskaya et al for review). These proteases cleave a specific extracellular amino-terminal domain of the receptor to reveal a tethered ligand, which in turn activates the receptor which couples via Gq to release intracellular calcium (Nystedt, S. et al., 1995). PAR4 is expressed in the vasculature, GI tract, leukocytes, lung, and heart. PAR4 is a relevant target for coronary thromboses, inflammatory bowel disease and cancer.

Product Information
Catalog #:	ACC-RG0922
Gene Name	F2RL3
Abbr	CHO-HuF2RL3
Alias	F2RL3,PAR4,PAR-4
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	F2RL3,PAR4,PAR-4