Galanin is a 29-30 amino acid peptide originally purified from intestine but later found to be abundant in the CNS. A family of 3 GPCRs, GAL1, GAL2 and GAL3, bind to galanin and mediate its biological effects. GAL1 couples to Gi/o to decrease intracellular cAMP levels. Galanin and its receptors have been implicated in pain, cognition, seizure activity, depression and drug addiction. In particular, GAL1 mediates the anticonvulsant activity of galanin; mice lacking GAL1 are affected by spontaneous seizures, and have increased susceptibility to seizures induced by lithium-pilocarpine treatment and electrical perforant path stimulation.

Product Information
Catalog #:	ACC-RG1160
Gene Name	GALR1
Abbr	CHO-HuGALR1 Validated
Alias	GALR1,GALNR,GALNR1,GAL1-R,GALR-1
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	GALR1,GALNR,GALNR1,GAL1-R,GALR-1

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