The human glucagon receptor GCGR mediates the action of the pancreatic peptide hormone glucagon. Glucagon regulates blood glucose via control of hepatic glycogenolysis and gluconeogenesis and via regulation of insulin release from the beta cell. Type 2 diabetes is characterized by inappropriate regulation of hepatic glucose production, which is due to an imbalance in the bihormonal relationship between plasma levels of glucagon and insulin. The glucose-lowering effects of glucagon peptide antagonists and anti-glucagon antibodies have demonstrated the potential of glucagon receptor antagonism as a treatment for type 2 diabetes. Glucagon also elicits various effects in extrahepatic tissues, including adipose tissue, kidney, heart, pancreatic beta cells, gastrointestinal tract, thyroid and central nervous system.

Product Information
Catalog #:	ACC-RG0442
Gene Name	GCGR
Abbr	HEK293T-HuGCGR-FLAG
Alias	GCGR,GGR,GL-R,FLJ97182,MGC138246
Growth Properties	Adherent
Host Cell	HEK293T
Morphology	Epithelial
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	GCGR,GGR,GL-R,FLJ97182,MGC138246

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