Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid >acifran >5-methyl nicotinic acid = acipimox >>nicotinuric acid = nicotinamide
Product Information | |
---|---|
Catalog #: | ACC-RG0544 |
Gene Name | HCAR2 |
Abbr | CHO-HuHCAR2/Gi/Go |
Alias | HCAR2,GPR109A,HCA2,HM74A,NIACR1,PUMAG,HM74a,HM74b,Puma-g,GPR109A |
Growth Properties | Adherent |
Host Cell | CHO-K1 |
Morphology | Epithelial-like |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | HCAR2,GPR109A,HCA2,HM74A,NIACR1,PUMAG,HM74a,HM74b,Puma-g,GPR109A |
Related Products
Catalog | Product Name | Gene Name | Species | Morphology | Price |
---|---|---|---|---|---|
ACC-RG1680 | Human HCAR2 Stable Cell Line-CHO-K1/Gα15 | HCAR2 | Human | INQUIRY | |
ACC-RG0708 | Human HCAR2/Galpha15 Stable Cell Line-Chem-4 | HCAR2 | Human | INQUIRY | |
ACC-RG1315 | Human HCAR2/Apoaequorin Stable Cell Line-CHO | HCAR2 | Human | Epithelial-like | INQUIRY |
ACC-RG0337 | Human HCAR2-FLAG Stable Cell Line-CHO | HCAR2 | Human | Epithelial-like | INQUIRY |
ACC-RG1193 | Human HCAR2 Validated Stable Cell Line-CHO | HCAR2 | Human | Epithelial-like | INQUIRY |
ACC-RG1516 | Human HCAR2/beta-Arrestin Stable Cell Line-CHO | HCAR2 | Human | Epithelial-like | INQUIRY |
Inquiry