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Human HCN4 Stable Cell Line-CHO

HCN4 is the major Hyperpolarization-activated Cyclic Nucleotide-gated ion channel in the mammalian heart. They are voltage-gated, cation channels, typically closed at resting and depolarized membrane potentials. The action of HCN4 is essential for the rhythmicity of the heart beat as well as controlling the strength of the contraction. HCN4 is expressed in the heart and brain, but significantly, not in the retina. The side effects of many anti-arrhythmic drugs include visual disturbances; a selective HCN4 blocker would potentially slow the heart rate without affecting vision. Safety screening, to detect undesirable action on HCN4 channels, is essential to assess the cardiac liability of new drug submissions.

Product Information
Catalog #:  ACC-RI0014
Gene Name HCN4
Abbr CHO-HuHCN4
Alias HCN4,SSS2
Growth Properties Adherent
Host Cell CHO-K1
Morphology Epithelial-like
Shipping Dry ice
Product Type Ion Channel Expressing Cell
Channel Type Other Voltage-gated Ion Channel
Channel Subgroup HCN Channel
Species Human
Product Format frozen
searchKeyword HCN4,SSS2

Related Products

Catalog Product Name Gene Name Species Morphology Price
ACC-RI0102 Human HCN4 Stable Cell Line-HEK293 HCN4 Human Epithelial INQUIRY
Our products are only for research use. Not intended for any clinical or diagnostic use.

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