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Human HTR2A Validated Stable Cell Line-CHO
5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT2A, which couples to Gq/11 to increase intracellular calcium, is widely expressed at central and peripheral sites of 5-HT action, and contributes to many of the physiological effects of 5-HT. The hallucinogenic activity of LSD is mediated in part by its action as an partial to full agonist at 5-HT2A, and the activity of atypical antipsychotics such as clozapine appears to be mediated in part by antagonism of 5-HT2A.
| Product Information | |
|---|---|
| Catalog #: | ACC-RG1102 |
| Gene Name: | HTR2A |
| Abbr | CHO-HuHTR2A Validated |
| Alias | HTR2A,HTR2,5 HT2A,5-HT-2A,HTR2,5-HT2A |
| Growth Properties | Adherent |
| Host Cell | CHO-K1 |
| Morphology | Epithelial-like |
| Product Format | frozen |
| Product Type | GPCR Expressing Cell |
| searchKeyword | HTR2A,HTR2,5 HT2A,5-HT-2A,HTR2,5-HT2A |
| Shipping | Dry ice |
| Species | Human |
Related Products
| Catalog | Product Name | Gene Name | Species | Morphology | Price |
|---|---|---|---|---|---|
| ACC-RG0022 | Human HTR2A Stable Cell Line-U2OS | HTR2A | Human | Epithelial | INQUIRY |
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