The human KCNH3 gene encodes for the pore-forming subunit of the subfamily H (eag-related) voltage-gated potassium channel #3, a protein known as the Kv12.2 potassium ion channel. The gene was cloned & first described as BEC1 by Miyake et al. 1999. Gene deletion experiments in mice showed KCNH3 knock-out mice performed better in working memory, reference memory, and attention-related behavioral assays than their wild-type littermates; enhanced performance was also observed in heterozygous mutants. Interestingly, when KCNH3 was overexpressed in the forebrain impaired performance was observed in the behavioral assays. Altering KCNH3 expression changed hippocampal neuronal excitability and synaptic plasticity; suggesting that Kv12.2 could be an interesting target for cognitive enhancement or perhaps epilepsy.
|Product Type||Ion Channel Expressing Cell|
|Channel Type||Potassium Channel|
|Channel Subgroup||Voltage-gated (Kv)|