Molecular cloning has identified the channel as a heteromer comprised of four pore-forming subunits, termed Kir 6.2, and four auxiliary sulphonylurea receptor subunits, Sur2A. The channel is gated by intracellular ATP and NDP while the Sur2A is regulated by both agonists, such as the potassium channel opener pinacidil, and antagonists, such as glibenclamide. In vivo the cardiac KATP channel is thought to be cardioprotective during periods of ischemic stress, as activation of the channel hyperpolarizes the cell, reducing calcium channel activity, leading to a shortening of the action potential duration.

Product Information
Catalog #:	ACC-RI0025
Gene Name	KCNJ11/MED23
Abbr	HEK293-HuKCNJ11/MED23
Alias	MED23,SUR2,CRSP3,MRT18,SUR-2,ARC130,
Growth Properties	Adherent
Host Cell	HEK293
Morphology	Epithelial
Shipping	Dry ice
Product Type	Ion Channel Expressing Cell
Channel Type	Potassium Channel
Channel Subgroup	Inwardly rectifying (Kir)
Species	Human
Product Format	frozen
searchKeyword	MED23,SUR2,CRSP3,MRT18,SUR-2,ARC130,