In Mammals, one of the most physiologically-relevant and studied currents is the M current, named this because it is a current observed in neurons in response to addition of muscarine. The M current is inhibited by various brain peptides and M1 muscarinic acetycholine GPCRS. M currents are recorded from brain tissue are all thought to contain Kv7.3, and one combination that appears to be responsible for making M current in neurons in Kv 7.3 with Kv 7.5. These subunits are preferentially expressed in brain & sympathetic ganglia. Openers active on brain currents limit repetitive firing, and their ability to modulate overactivity in dopaminergic & serotonergic pathways is of therapeutic interest for schizophrenia, drug abuse and anxiety.

Product Information
Catalog #:	ACC-RI0044
Gene Name	KCNQ3/KCNQ5
Abbr	CHO-HuKCNQ3/KCNQ5
Alias	KCNQ5,Kv7.5
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	Ion Channel Expressing Cell
Channel Type	Potassium Channel
Channel Subgroup	Voltage-gated (Kv)
Species	Human
Product Format	frozen
searchKeyword	KCNQ5,Kv7.5