P2Y1 is a receptor for ATP and ADP. P2Y1 contributes to platelet shape change. A number of P2Y1 receptor-specific antagonists, such as, MRS-2179, A3P5PS, A3P5P and A2P5P have been discovered. They inhibit calcium ion mobilization and shape change in platelets. P2Y1-deficient mice and mice treated with the P2Y1 antagonist MRS2179 displayed significantly less arterial thrombosis than their respective controls. Combination of P2Y1 deficiency with P2Y12 inhibition led to a significant additive effect.
Product Information | |
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Catalog #: | ACC-RG0371 |
Gene Name | P2RY1 |
Abbr | 1321N1-HuP2RY1 |
Alias | P2RY1,P2Y1 |
Growth Properties | Adherent |
Host Cell | 1321N1 |
Morphology | Glial |
Shipping | Dry ice |
Product Type | GPCR Expressing Cell |
Species | Human |
Product Format | frozen |
searchKeyword | P2RY1,P2Y1 |
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