P2Y1 is a receptor for ATP and ADP. P2Y1 contributes to platelet shape change. A number of P2Y1 receptor-specific antagonists, such as, MRS-2179, A3P5PS, A3P5P and A2P5P have been discovered. They inhibit calcium ion mobilization and shape change in platelets. P2Y1-deficient mice and mice treated with the P2Y1 antagonist MRS2179 displayed significantly less arterial thrombosis than their respective controls. Combination of P2Y1 deficiency with P2Y12 inhibition led to a significant additive effect.
| Product Information | |
|---|---|
| Catalog #: | ACC-RG0371 |
| Gene Name: | P2RY1 |
| Abbr | 1321N1-HuP2RY1 |
| Alias | P2RY1,P2Y1 |
| Growth Properties | Adherent |
| Host Cell | 1321N1 |
| Morphology | Glial |
| Product Format | frozen |
| Product Type | GPCR Expressing Cell |
| searchKeyword | P2RY1,P2Y1 |
| Shipping | Dry ice |
| Species | Human |
Related Products
| Catalog | Product Name | Gene Name | Species | Morphology | Price |
|---|---|---|---|---|---|
| ACC-RG0912 | Human P2RY1 Stable Cell Line-1321N1 astrocytoma | P2RY1 | Human | Glial | INQUIRY |
Inquiry