The P2Y GPCRs serve as receptors for extracellular nucleotides. P2Y2 (also known as P2U) is activated by UTP and ATP, and couples to Gq to increase intracellular calcium. The P2Y2 receptor knockout mouse displays defective nucleotide-stimulated Cl-secretion, and a P2Y2 selective agonist increases tracheal epithelial chloride and water secretion. As a result, P2Y2 is a potential target for treatment of cystic fibrosis. In addition, the P2Y2 KO mouse displays salt-resistant hypertension.

Product Information
Catalog #:	ACC-RG0724
Gene Name	P2RY2
Abbr	1321N1-HuP2RY2/Galpha15
Alias	P2RY2,HP2U,P2RU1,P2U,P2U1,P2UR,P2Y2,P2Y2R
Growth Properties	Adherent
Host Cell	1321N1
Morphology	Glial
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	P2RY2,HP2U,P2RU1,P2U,P2U1,P2UR,P2Y2,P2Y2R

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