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- Human PTGER2 Validated Stable Cell Line-HEK293
Human PTGER2 Validated Stable Cell Line-HEK293
Prostanoids bind to a family of 8 GPCRs to exert their biological effects. The protanoid PGE2 causes pain, vasodilation, immunosuppression of T cells, bone resorption and promotion of carcinogenesis. Four related GPCRs, EP1, EP2, EP3 and EP4, each bind to PGE2, but the different G protein coupling status of each receptor leads to distinct biological effects. EP2 couples primarily to Gs to increase intracellular cAMP levels. Mice deficient in EP2 receptor showed impaired ovulation and fertilization, salt-sensitive hypertension. It has been shown that EP2 receptors are also involved in cancer associated immunodeficiency. Thus, genetic knockout of the EP2 receptor reduced tumor growth and prolonged survival in mice that had undergone isograft injection of MC26 or Lewis lung carcinoma cells.
| Product Information | |
|---|---|
| Catalog #: | ACC-RG1204 |
| Gene Name | PTGER2 |
| Abbr | HEK293-HuPTGER2 Validated |
| Alias | PTGER2 |
| Growth Properties | Adherent |
| Host Cell | HEK293 |
| Morphology | Epithelial |
| Shipping | Dry ice |
| Product Type | GPCR Expressing Cell |
| Species | Human |
| Product Format | frozen |
| searchKeyword | PTGER2 |
Related Products
| Catalog | Product Name | Gene Name | Species | Morphology | Price |
|---|---|---|---|---|---|
| ACC-RG1772 | Human PTGER2 Stable Cell Line - CHO-K1/Gα15 | PTGER2 | Human | INQUIRY | |
| ACC-RG0360 | Human PTGER2-FLAG Stable Cell Line-HEK293T | PTGER2 | Human | Epithelial | INQUIRY |
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