Nav1.8 is a voltage-gated sodium channel alpha subunit. It is expressed in mammalian adult dorsal root ganglion (DRG) neurons, predominantly those with small diameter cell bodies that give rise to the unmyelinated (C-type) fibres. These fibres form synapses in the dorsal horn of the spinal cord and are mainly involved in pain signaling. This channel conducts the characteristic slow, tetrodotoxin-resistant (TTX-r) currents involved in action potential initiation and transmission in these neurons and is therefore a potential target for analgesic agents. Altered expression of Nav1.8 is observed in pain models and human pain states-channel protein can be seen to re-localise from cell bodies to the site of insult or injury. There is also good evidence from antisense oligonucleotide studies for a role in development of hyperexciteable states in pain models. However KO mice show surprisingly limited pain phenotypes, possibly due to compensatory up-regulation of other Nav subtypes. Native sodium channels are multi-subunit complexes, composed of not only the pore forming alpha subunit, but also auxiliary beta subunits. The beta1 subunit is known to increase peak current amplitude as well as increasing sodium ion channel expression at the cell surface.

Product Information
Catalog #:	ACC-RI0054
Gene Name	SCN10A
Abbr	HEK293-HuSCN10A
Alias	SCN10A,hPN3,Nav1.8,PN3,SNS
Growth Properties	Adherent
Host Cell	HEK293
Morphology	Epithelial
Shipping	Dry ice
Product Type	Ion Channel Expressing Cell
Channel Type	Sodium Channel
Species	Human
Product Format	frozen
searchKeyword	SCN10A,hPN3,Nav1.8,PN3,SNS