Neurokinin 3 receptor is the gene that encodes a protein that is one of the three Neurokinin receptors (NKRs), also termed as TACRs. The Neurokinin receptor family is a group of Gcoupled receptors whose principal ligands are the Neurokinins. This protein family encompasses a wide range of functions including various parachine, autocrine and endocrine processes. NK3 receptors are distributed widely throughout the CNS, and are found in high levels in the cerebral cortex, basal ganglia and dorsal horn of the spinal chord. They have a limited distribution in peripheral tissues, and are found in ganglia (e.g., myenteric plexus), kidney, and in a limited number of smooth muscles (e.g., rat portal vein). NK3 antagonist has been proposed as antipsychotics.

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