The migration of leukocytes from the bloodstream to sites of inflammation is a dynamic factor involving adhesion molecules and chemotactic factors. Chemokines play a role in the trafficking of leukocytes by inducing cellular motility and activating adhesion molecules within the immune system. Lymphotactin (also known as XCL1 and SCM-1) is a unique chemokine that retains only two of the four cysteine residues found in the CC, CXC and CX3C families of chemokines. A Gi-coupled receptor, XCR1, binds to lymphotactin and mediates its chemotactic effects. Chemokines promote accumulation of activated mononuclear cells (MNCs) in inflamed joints in rheumatoid arthritis (RA) and lymphotacin is highly expressed in synovial fluid of RA patients. In situ hybridization studies indicate that XCR1 expression was detected in both the infiltrated MNCs and the synoviocytes from synovial specimens taken from RA patients.

Product Information
Catalog #:	ACC-RG1269
Gene Name	XCR1
Abbr	CHO-HuXCR1/Apoaequorin
Alias	XCR1,CCXCR1,GPR5
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	XCR1,CCXCR1,GPR5

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