The migration of leukocytes from the bloodstream to sites of inflammation is a dynamic factor involving adhesion molecules and chemotactic factors. Chemokines play a role in the trafficking of leukocytes by inducing cellular motility and activating adhesion molecules within the immune system. Lymphotactin (also known as XCL1 and SCM-1) is a unique chemokine that retains only two of the four cysteine residues found in the CC, CXC and CX3C families of chemokines. A Gi-coupled receptor, XCR1, binds to lymphotactin and mediates its chemotactic effects. Chemokines promote accumulation of activated mononuclear cells (MNCs) in inflamed joints in rheumatoid arthritis (RA) and lymphotacin is highly expressed in synovial fluid of RA patients. In situ hybridization studies indicate that XCR1 expression was detected in both the infiltrated MNCs and the synoviocytes from synovial specimens taken from RA patients.

Product Information
Catalog #:	ACC-RG1148
Gene Name	XCR1
Abbr	CHO-HuXCR1 Validated
Alias	XCR1,CCXCR1,GPR5
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	XCR1,CCXCR1,GPR5

Related Products

Catalog	Product Name	Gene Name	Species	Morphology	Price
ACC-RG1782	Mouse Xcr1 Stable Cell Line - CHO	Xcr1	Mouse		INQUIRY
ACC-RG0229	Human XCR1-FLAG Stable Cell Line-HEK293T	XCR1	Human	Epithelial	INQUIRY
ACC-RG1269	Human XCR1/Apoaequorin Stable Cell Line-CHO	XCR1	Human	Epithelial-like	INQUIRY