Muscarinic acetylcholine receptors are members of the superfamily of G protein-coupled receptors (GPCRs). They are relatively abundant and mediate many of the diverse actions of acetylcholine in the CNS as well as throughout non-nervous tissues innervated by the parasympathetic nervous system. At present, five receptor subtypes (M1 - M5) have been identified. The odd-numbered receptors (M1, M3, and M5) are preferentially coupled to G(q/11). The even-numbered receptors (M2 and M4) are coupled to G(i/o). They also activate G protein-gated potassium channels, which leads to hyperpolarization of the plasma membrane in different excitable cells. Among the five subtypes, M1 receptor is important in excitatory postsynaptic potential in autonomic ganglia, secretion from salivary glands and stomach, memory and Alzheimers disease.

Product Information
Catalog #:	ACC-RG0872
Gene Name	CHRM1
Abbr	CHO-HuCHRM1
Alias	CHRM1,M1,HM1,M1R,MGC30125
Growth Properties	Adherent
Host Cell	CHO-K1
Morphology	Epithelial-like
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Stability	12 passages (6 weeks of continuous culture)
Product Format	frozen
searchKeyword	CHRM1,M1,HM1,M1R,MGC30125

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