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- Human HTR2C(not edited) Validated Stable Cell Line-1321N1
Human HTR2C(not edited) Validated Stable Cell Line-1321N1
5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT2C, which couples to Gq in most cells to stimulate intracellular calcium, is prominently expressed in brain and appears to modulate depression, anxiety and appetite. The mRNA encoding 5-HT2C undergoes selective RNA editing that changes 4 amino acids in the second intracellular loop; these changes result in alteration of efficiency of coupling to G proteins. Alterations in editing of 5-HT2C have been detected in victims of suicidal depression and in mice treated with the SSRI, fluoxetine.
| Product Information | |
|---|---|
| Catalog #: | ACC-RG1105 |
| Gene Name | HTR2C |
| Abbr | 1321N1-HuHTR2C(not edited) Validated |
| Alias | HTR2C,HTR1C,5 HT2C,5-HT1C,5-HT-1C,5-HT-2C,HTR1C,5-HT2C,5-HTR2C |
| Growth Properties | Adherent |
| Host Cell | 1321N1 |
| Morphology | Glial |
| Shipping | Dry ice |
| Product Type | GPCR Expressing Cell |
| Species | Human |
| Product Format | frozen |
| searchKeyword | HTR2C,HTR1C,5 HT2C,5-HT1C,5-HT-1C,5-HT-2C,HTR1C,5-HT2C,5-HTR2C |
Related Products
| Catalog | Product Name | Gene Name | Species | Morphology | Price |
|---|---|---|---|---|---|
| ACC-RG1629 | Human HTR2C Stable Cell Line-HEK293 | HTR2C | Human | INQUIRY | |
| ACC-RG0783 | Human HTR2C Stable Cell Line-CHO | HTR2C | Human | Epithelial-like | INQUIRY |
| ACC-RG1104 | Human HTR2C(edited) Validated Stable Cell Line-CHO | HTR2C | Human | Epithelial-like | INQUIRY |
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