5-Hydroxytryptamine (5-HT, also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals. In the periphery, 5-HT mediates gastrointestinal motility, platelet aggregation, and contraction of blood vessels. Many functions of the central nervous system are influenced by 5-HT, including sleep, motor activity, sensory perception, arousal and appetite. A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT. 5-HT2C, which couples to Gq in most cells to stimulate intracellular calcium, is prominently expressed in brain and appears to modulate depression, anxiety and appetite. The mRNA encoding 5-HT2C undergoes selective RNA editing that changes 4 amino acids in the second intracellular loop; these changes result in alteration of efficiency of coupling to G proteins. Alterations in editing of 5-HT2C have been detected in victims of suicidal depression and in mice treated with the SSRI, fluoxetine.

Product Information
Catalog #:	ACC-RG1105
Gene Name	HTR2C
Abbr	1321N1-HuHTR2C(not edited) Validated
Alias	HTR2C,HTR1C,5 HT2C,5-HT1C,5-HT-1C,5-HT-2C,HTR1C,5-HT2C,5-HTR2C
Growth Properties	Adherent
Host Cell	1321N1
Morphology	Glial
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	HTR2C,HTR1C,5 HT2C,5-HT1C,5-HT-1C,5-HT-2C,HTR1C,5-HT2C,5-HTR2C

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