Human KCNH2 Stable Cell Line-HEK293

The human KCNH2 gene encodes the pore-forming subunit of Kv11.1, the voltage-gated hERG potassium channel. HERG channels are upregulated in some types of cancer and may serve as a tumor marker. KCNH2 mutations cause inherited forms of cardiac disorders including both long QT (loss-of-function) and short QT (gain-of-function) syndromes. Inhibition of HERG channels by pharmaceuticals is the primary cause of acquired long QT syndrome and drug-induced torsade de pointe. Therefore, HERG is an anti-target in cardiac risk assessment.

Product Information
Catalog #:	ACC-RI0135
Gene Name	KCNH2
Abbr	HEK293-HuKCNH2
Alias	KCNH2,LQT2,erg1,HERG,Kv11.1,ERG-1,H-ERG,hERG-1,ERG1,SQT1,HERG1
Growth Properties	Adherent
Host Cell	HEK293
Morphology	Epithelial
Shipping	Dry ice
Product Type	Ion Channel Expressing Cell
Channel Type	Potassium Channel
Channel Subgroup	Voltage-gated (Kv)
Species	Human
Product Format	frozen
searchKeyword	KCNH2,LQT2,erg1,HERG,Kv11.1,ERG-1,H-ERG,hERG-1,ERG1,SQT1,HERG1