The human KCNQ2 and KCNQ4 genes encode the pore-forming subunits of Kv7.2 and Kv7.4, respectively. These subunits form heteromeric voltage-gated potassium channels that underlie M-current that regulates repetitive activity in neurons. Mutations in KCNQ2 that reduce M-current are responsible for some forms of benign familial neonatal seizure. KCNQ4 loss-of-function mutations cause hereditary deafness. Kv7.2/Kv7.4 channels are therapeutic targets in seizure and neuropathic pain.
Product Information | |
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Catalog #: | ACC-RI0146 |
Gene Name | KCNQ4 |
Abbr | CHO-HuKCNQ2/KCNQ4 |
Alias | KCNQ4,DFNA2,Kv7.4,KV7.4,DFNA2A |
Growth Properties | Adherent |
Host Cell | CHO |
Morphology | Epithelial-like |
Shipping | Dry ice |
Product Type | Ion Channel Expressing Cell |
Channel Type | Potassium Channel |
Channel Subgroup | Voltage-gated (Kv) |
Species | Human |
Product Format | frozen |
searchKeyword | KCNQ4,DFNA2,Kv7.4,KV7.4,DFNA2A |
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ACC-RI0045 | Human KCNQ4 Stable Cell Line-HEK293 | KCNQ4 | Human | Epithelial | INQUIRY |
ACC-RI0148 | Human KCNQ4 Stable Cell Line-CHO | KCNQ4 | Human | Epithelial-like | INQUIRY |
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