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- Human KCNQ4 Stable Cell Line-HEK293
Human KCNQ4 Stable Cell Line-HEK293
KCNQ genes encode potassium channels that have been associated with both cardiac and hearing abnormalities in humans, most notably the KNCQ1 gene. Using a partial KCNQ3 cDNA Kubisch et al. screened a human retinal cDNA lambda phage library and obtained a novel homolog they named KCNQ4. When expressed in Xenopus oocytes KCNQ4 encodes a potassium current inhibited by 30% in the presence of 200 μM linopridine, whereas the current due to KCNQ3/KCNQ4 heteromers in the same study was inhibited by 75% at that concentration. Kubisch et al. also mapped the KCNQ4 gene to the 1p34 human chromosome, in a region associated with autosomal dominant deafness DFNA2A. Subsequent studies have identified additional families with mutations in KCNQ4 and hearing loss. KCNQ4-specific openers could possibly treat progressive hearing loss and tinnitus Kubisch et al..
| Product Information | |
|---|---|
| Catalog #: | ACC-RI0045 |
| Gene Name | KCNQ4 |
| Abbr | HEK293-HuKCNQ4 |
| Alias | KCNQ4,DFNA2,Kv7.4,KV7.4,DFNA2A |
| Growth Properties | Adherent |
| Host Cell | HEK293 |
| Morphology | Epithelial |
| Shipping | Dry ice |
| Product Type | Ion Channel Expressing Cell |
| Channel Type | Potassium Channel |
| Channel Subgroup | Voltage-gated (Kv) |
| Species | Human |
| Product Format | frozen |
| searchKeyword | KCNQ4,DFNA2,Kv7.4,KV7.4,DFNA2A |
Related Products
| Catalog | Product Name | Gene Name | Species | Morphology | Price |
|---|---|---|---|---|---|
| ACC-RI0148 | Human KCNQ4 Stable Cell Line-CHO | KCNQ4 | Human | Epithelial-like | INQUIRY |
| ACC-RI0146 | Human KCNQ2/KCNQ4 Stable Cell Line-CHO | KCNQ4 | Human | Epithelial-like | INQUIRY |
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