Human SCN9A Stable Cell Line-HEK293

Nav1.7 is a voltage-gated sodium channel alpha subunit. It is expressed in all types of DRG neurons, sympathetic neurons, Schwann cells and neuroendocrine cells. This channel is involved in action potential initiation and transmission in peripheral neurons and is a potential target for local anaesthetic agents. Specific hereditary mutations in the gene encoding Nav1.7, SCN9A, result in the painful neuropathies, erythermalgia and paroxysmal extreme pain disorder, that can be ascribed to altered firing of pain sensing neurons. Changes in the expression levels of the channel correlates with increases in neuronal excitability in acute and chronic pain syndromes. Hence due to their relatively discrete location and fundamental role in mediating certain types of pain they may be promising targets for pharmacological intervention.

Product Information
Catalog #:	ACC-RI0053
Gene Name	SCN9A
Abbr	HEK293-HuSCN9A
Alias	SCN9A,ETHA,Nav1.7,NE NA,NENA,PN1,hNE-Na,SFNP,FEB3B,NE-NA,GEFSP7
Growth Properties	Adherent
Host Cell	HEK293
Morphology	Epithelial
Shipping	Dry ice
Product Type	Ion Channel Expressing Cell
Channel Type	Sodium Channel
Species	Human
Product Format	frozen
searchKeyword	SCN9A,ETHA,Nav1.7,NE NA,NENA,PN1,hNE-Na,SFNP,FEB3B,NE-NA,GEFSP7