Mu opioid receptor (MOR) is a receptor for beta-endorphin, inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. MOR signaling and regulation are strongly agonist-dependent. MOR mediates positive reinforcement following direct (morphine) or indirect (alcohol, cannabinoids, nicotine) activation. MOR plays a genetic role in the control of gut inflammation. MOR-deficient mice are highly susceptible to colon inflammation, with a 50% mortality rate occurring 3 days after administration of TNBS that induces inflammation. MOR agonists regulate cytokine production and T cell proliferation and might be new therapeutic molecules in inflammatory bowel disease.
| Product Information | |
|---|---|
| Catalog #: | ACC-RG0344 |
| Gene Name: | Oprm1 |
| Abbr | CHO dhfr--RatOprm1 |
| Alias | OPRM1,MOR-1,MUOR1,M-OR-1,MORA,Oprm,Oprrm1 |
| Growth Properties | Adherent |
| Host Cell | CHO dhfr- |
| Morphology | Epithelial-like |
| Product Format | frozen |
| Product Type | GPCR Expressing Cell |
| searchKeyword | OPRM1,MOR-1,MUOR1,M-OR-1,MORA,Oprm,Oprrm1 |
| Shipping | Dry ice |
| Species | Rat |
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| ACC-RG0896 | Human OPRM1 Stable Cell Line-CHO | OPRM1 | Human | Epithelial-like | INQUIRY |
| ACC-RG0052 | Human OPRM1-SNAP Stable Cell Line-CHO | OPRM1 | Human | Epithelial-like | INQUIRY |
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