P2Y12 is a Gi-coupled 7TM receptor belonging to the P2Y family of nucleotide receptors. The principle ligand for P2Y12 in vivo is ADP, although it binds with lesser affinity to ATP. P2Y12 is expressed predominantly in platelets, where it mediates ADP-induced stable aggregation and secretion. The antithrombotic drugs clopidogrel and ticlopidine disrupt P2Y12-mediated platelet aggregation, and are indicated in acute coronary syndromes. However, metabolites of each drug that are generated by hepatic cytochrome P450 activity are the actual entities that bind and antagonize P2Y12 directly. Novel P2Y12 antagonists that bind directly to P2Y12 exhibit a faster onset of action, and are undergoing clinical trials.

Product Information
Catalog #:	ACC-RG0722
Gene Name	P2RY12
Abbr	U2OS-HuP2RY12/Galpha15
Alias	P2RY12,HORK3,P2Y12,SP1999,ADPG-R,BDPLT8,P2T(AC),P2Y(AC),P2Y(ADP),P2Y(cyc)
Growth Properties	Adherent
Host Cell	U2OS
Morphology	Epithelial
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Product Format	frozen
searchKeyword	P2RY12,HORK3,P2Y12,SP1999,ADPG-R,BDPLT8,P2T(AC),P2Y(AC),P2Y(ADP),P2Y(cyc)

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