The human P2Y12 is an ADP receptor involved in platelet aggregation. ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Activation of P2Y1 stimulates phospholipase C and triggers shape change, while P2Y12 coupled to Gi also involved in modulating thrombosis and hemostasis and therefore is a good drug target for antithrombotic drugs. P2Y receptors are expressed in a variety of tissues including platelets, endothelia, smooth muscle, CNS, osteoblasts , beta-islet cells as well as in commonly used CHO-K1 and HEK293 cells. We therefore chose to express the P2Y12 receptor in 1321N1 astrocytoma cells, which have minimal endogenous receptor.

Product Information
Catalog #:	ACC-RG0916
Gene Name	P2RY12
Abbr	1321N1 astrocytoma expressing Gqi3-HuP2RY12
Alias	P2RY12,HORK3,P2Y12,SP1999,ADPG-R,BDPLT8,P2T(AC),P2Y(AC),P2Y(ADP),P2Y(cyc)
Growth Properties	Adherent
Host Cell	1321N1 astrocytoma expressing Gqi3
Morphology	Glial
Shipping	Dry ice
Product Type	GPCR Expressing Cell
Species	Human
Stability	Stable up to 12 passages of continuous culture (6 weeks)
Product Format	frozen
searchKeyword	P2RY12,HORK3,P2Y12,SP1999,ADPG-R,BDPLT8,P2T(AC),P2Y(AC),P2Y(ADP),P2Y(cyc)

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