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ASICs

Acid-sensing ion channels (ASICs) are members of the amiloride-sensitive epithelial Na+-channel/degenerin superfamily (ENaC/DEG). These ligand-gated ion channels are activated by protons, which are released during tissue acidosis (increase in extracellular acidity). Tissue acidosis, which is evidenced by a drop in extracellular pH, occurs in many acute and chronic pain conditions including inflammation, angina, stroke, ischemic heart disease, arthritis, cancer and traumatic injuries. Protons have been shown to induce pain in humans and it is believed this signal may be mediated by ASICs.


1-2-7 ASICs.jpg

Fig. 1 Pharmacology of acid-sensing ion channels (ASICs) in human cortical neurons


This family of channels consists of six isoforms:

  • ASIC1a

  • ASIC1b

  • ASIC2a

  • ASIC2b

  • ASIC3

  • ASIC4

Of the six ASIC subunits, ASIC1 (1a/1b) and ASIC3 are attractive targets for the treatment of pain since primary sensory neurons are highly enriched with these channels. These primary afferent fibers are nociceptors that detect and signal painful sensations from the periphery to the brain. ASIC1a and ASIC3 are activated by an acidity range (pH 7.0-6.0) observed in several acute and chronic pain conditions. Moreover, ASIC3 is particularly sensitive to lactic acidosis and thus is considered to be an important component of acid-induced pain response during cardiac and muscle ischemia.

Here in Creative Bioarray, we provide target screening on a series of ASICs related to multiple diseases.

Reference

  1. Li M, et al. Acid-sensing ion channels in acidosis-induced injury of human brain neurons. J Cereb Blood Flow Metab. 2010; 30: 1247–1260.

Related Products

  • Overexpression Cell Line
Catalog Product Name Gene Name Species Morphology Price
ACC-RI0015 Human ASIC3 Stable Cell Line-HEK293 ASIC3 Human Epithelial INQUIRY
ACC-RI0065 Human ACCN3 Stable Cell Line-CHO ASIC3 Human Epithelial-like INQUIRY
ACC-RI0064 Human ACCN1 Stable Cell Line-CHO ASIC2 Human Epithelial-like INQUIRY
ACC-RI0062 Human ACCN2 Stable Cell Line-CHO ASIC1 Human Epithelial-like INQUIRY
For research use only.

Related Section

  • Sodium Channels
  • Calcium Channels
  • Potassium Channels
  • Chloride Channels
  • TRP Channels
  • ATP gated P2X Channels
  • Nicotinic Acetylcholine Receptors
  • Ionotropic Glutamate-gated Receptors
  • GABAa Receptors
  • Glycine Receptors
  • 5-HT Receptors3
  • Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)
  • Other Ion Channels

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