The human CACNA1A gene encodes the pore-forming subunit of Cav2.1, the voltage-gated P/Q-type calcium channel. Inclusion of auxiliary subunits modulate gating and pharmacological characteristics, while the inwardly rectifying potassium channel allows the membrane potential to be altered with changes in extracellular K+. Mutations in CACNA1A are responsible for several inherited neurologic disorders including, familial hemiplegic migraine, episodic ataxia type2, and spinocerebellar ataxia type 6 epilepsy. Cav2.1 channels expressed in neurons are therapeutic targets in pain.

Product Information
Catalog #:	ACC-RI0072
Gene Name	KCNJ2
Abbr	HEK293-HuCACNA1A/AP4B1/CACNA2D1/KCNJ2
Alias	KCNJ2,IRK1,Kir2.1,IRK-1,hIRK1,LQT7,SQT3,ATFB9,HHIRK1,KIR2.1,HHBIRK1
Growth Properties	Adherent
Host Cell	HEK293
Morphology	Epithelial
Shipping	Dry ice
Product Type	Ion Channel Expressing Cell
Channel Type	Potassium Channel
Channel Subgroup	Inwardly rectifying (Kir)
Species	Human
Product Format	frozen
searchKeyword	KCNJ2,IRK1,Kir2.1,IRK-1,hIRK1,LQT7,SQT3,ATFB9,HHIRK1,KIR2.1,HHBIRK1

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