The human CACNA1D gene encodes the pore-forming subunit of Cav1.3. CACNB3 and CACNA2D1 encode auxiliary subunits that modulate gating and pharmacological properties. The inducible expression of Kir2.1 provides a mechanism for K+-depolarization of the resting membrane potential to facilitate voltage-dependent activation of the Cav1.3 channels in FLIPR assays.
| Product Information | |
|---|---|
| Catalog #: | ACC-RI0070 | 
| Gene Name: | KCNJ2 | 
| Abbr | HEK293-HuCACNA1D/CACNB3/CACNA2D1 + KCNJ2(tetracycline-inducible) | 
| Alias | KCNJ2,IRK1,Kir2.1,IRK-1,hIRK1,LQT7,SQT3,ATFB9,HHIRK1,KIR2.1,HHBIRK1 | 
| Channel Subgroup | Inwardly rectifying (Kir) | 
| Channel Type | Potassium Channel | 
| Growth Properties | Adherent | 
| Host Cell | HEK293 | 
| Morphology | Epithelial | 
| Product Format | frozen | 
| Product Type | Ion Channel Expressing Cell | 
| searchKeyword | KCNJ2,IRK1,Kir2.1,IRK-1,hIRK1,LQT7,SQT3,ATFB9,HHIRK1,KIR2.1,HHBIRK1 | 
| Shipping | Dry ice | 
| Species | Human | 
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