Creative Bioarray
  • USA:
  • Europe:
LOGO
  • Home
    • About Us
    • Contact Us
    • Events
  • Screening
    • Ionic Screening Service
      • Ion Flux Assay
      • Fluorescence Assay
      • Patch-clamp Assay
    • Ionic Screening Panel
      • Sodium Channels
      • Potassium Channels
      • Chloride Channels
      • Calcium Channels
      • TRP Channels
      • ATP gated P2X Channels
      • ASICs
      • Nicotinic Acetylcholine Receptors
      • Ionotropic Glutamate-gated Receptors
      • GABAa Receptors
      • Glycine Receptors
      • 5-HT Receptors3
      • Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)
      • Other Ion Channels
    • Stable Cell Lines
      • Ion Channel Expressing Cell
      • GPCR Expressing Cell
      • Other Membrane Receptors/Transporters/Exchangers Expression Cell
      • Customized Ionic Channel Expression System
  • Cardiology
    • Cardiac Ion Channel Screen Panels
      • HERG (IKR, KV11.1)
      • Cav1.2
      • Kv4.3
      • KCNQ1/mink/Kv7.1
      • Kir2.1
      • Nav1.5
      • Kv1.5
      • HCN1&HCN4
      • Other Ion Channels
    • CiPA
      • CiPA Cardiac Channel Assays
      • CiPA In silico Modeling
      • CiPA Translational Assays
    • 3D Cardiotoxicity
    • Cardiomyocyte Functions
      • Action Potential Properties
      • Calcium Transient in Cardiomyocytes
      • QT Service Using Langendorff Perfused Heart
    • Cardiac in vivo Assays
      • QRS, QT Waves Detection by ECG
  • Neurology
    • Neurotransmission Functions
      • sEPSC/sIPSC Recordings
      • fEPSP / Populational Spikes Recordings
      • LTP & LTD Formation or Deficit Detection
    • Basic Neuronal Activity
      • Action Potential Properties Assay
      • NMDA/AMPA Ratio Test
      • Calcium Signaling Test
      • Customized Electrophysiological Test
    • Neuronal in vivo Assays
      • In vivo Extra-cellular Recordings/Whole-cell Patch-clamp Recordings
      • Continuous Telemetric EEG Recordings
    • Animal Behavior Tests
      • Spontaneous Locomotor Functions
      • Cognitive Functions
      • Anxiety-Depression and Social Interaction Evaluation
      • Assays for Neuropsychiatric Disorders
  • Ophthalmology
  • Platform
    • Experiment Systems
      • Xenopus Oocyte Screening Model
      • Acute Isolated Cardiomyocytes
      • Acute Dissociated Neurons
      • Primary Cultured Neurons
      • Cultured Neuronal Cell Lines
      • iPSC-derived Cardiomyocytes/Neurons
      • Acute/Cultured Organotypic Brain Slices
      • Oxygen Glucose Deprivation Model
      • 3D Cell Culture
      • iPSC-derived Neurons
      • Isolation and culture of neural stem/progenitor cells
    • Animal Models
      • Alzheimer's Disease Model
      • Parkinson's Disease Model
      • Huntington's Disease Model
      • Epilepsy Model
      • ALS Model
      • Psychiatric Model
      • Autism Spectrum Disorder
      • Cerebral-Spinal Injury Model
      • Pain Model
      • Stroke Model
      • Fragile X Model
      • Acute/Chronic Heart Failure Model
    • Techinques
      • Manual Patch-clamp Technique
      • Automated Patch-clamp
      • Multi-Electrode Array (MEA)
      • FluxOR™ Thallium Assay
      • FLIPR Detection System
      • Optogenetics
      • Neuronal Tract Tracing
    • Resource
      • Technical Methods
      • Neuroscience
      • Channelopathies
      • Channelomics
    • Equipment
  • Order
  • Careers
  • Home
  • Screening
  • Ionic Screening Panel
  • TRP Channels
  • Screening
  • Ionic Screening Service Ionic Screening Panel Stable Cell Lines
  • Cardiology
  • CiPA 3D Cardiotoxicity Cardiomyocyte Functions Cardiac in vivo Assays Cardiac Ion Channel Screen Panels
  • Neurology
  • Basic Neuronal Activity Neurotransmission Functions Neuronal in vivo Assays Animal Behavior Tests
  • Platform
  • Experiment Systems Animal Models Techinques Resource Equipment

TRP Channels

Transient receptor potential channels (TRP) are non-selective calcium permeant cation channel located mostly on the plasma membrane of numerous animal cell types. They are involved in osmotic sensitivity and mechano-sensitivity. The exposure to hypotonicity within the physiological range induces some TRP channels activation exhibiting an outward rectification. TRP channels can also be activated by heat, low pH, citrate and phorbol esters. The increase of intracellular Ca2+ potentiates TRP channel currents. TRP Channels play an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8.

Here at Creative Bioarray, we performed drug target screening analysis using novel fluorescent dyes, such as fluo-4 AM dye, we have completed implementation of high throughput screening for several TRP channels, including TRPC and TRPV channels. Other TRP channels target screening can also be obtained in Creative Bioarray.


1-2-5 TRP Channels-1.jpg

Fig. 1 Electrophysiological recording of TRPM2 activation in isolated phagosomes


There are about 28 TRP channels sharing some structural similarity to each other. TRPs mediate a variety of sensations including pain, extreme temperatures, taste and vision and are activated by a broad range of molecules including allicin, capsaicin and menthol. In the body, some TRP channels are thought to behave like microscopic thermometers and used in animals to sense hot or cold. Some TRP channels are activated by molecules found in spices like garlic (allicin), chilli pepper (capsaicin), wasabi (allyl isothiocyanate); others are activated by menthol, camphor, peppermint, and cooling agents; yet others are activated by molecules found in cannabis (i.e., THC, CBD and CBN) or stevia. Some act as sensors of osmotic pressure, volume, stretch, and vibration.

TRP channels can be sub-divided into 6 families:

  • TRPC (canonical)

  • TRPA (ankyrin)

  • TRPV (vanilloid)

  • TRPM (melastatin)

  • TRPP (polycystic)

  • TRPML (mucolipin)

Reference

  1. Di A, et al. Role of the phagosomal redox-sensitive TRP channel TRPM2 in regulating bactericidal activity of macrophages. J Cell Sci. 2017; 130: 735–744.

Related Products

  • Overexpression Cell Line
Catalog Product Name Gene Name Species Morphology Price
ACC-RI0058 Human TRPV3 Stable Cell Line-HEK293 TRPV3 Human Epithelial INQUIRY
ACC-RI0057 Human TRPV1 Stable Cell Line-HEK293 TRPV1 Human Epithelial INQUIRY
ACC-RI0056 Human TRPA1 Stable Cell Line-HEK293 TRPA1 Human Epithelial INQUIRY
ACC-RI0204 Human TRPV6 Stable Cell Line-HEK293 TRPV6 Human Epithelial INQUIRY
ACC-RI0203 Human TRPV4 Stable Cell Line-CHO TRPV4 Human Epithelial-like INQUIRY
ACC-RI0199 Human TRPM8 Stable Cell Line-CHO TRPM8 Human Epithelial-like INQUIRY
ACC-RI0198 Human TRPM4 Stable Cell Line-HEK293 TRPM4 Human Epithelial INQUIRY
ACC-RI0196 Human TRPM4 Stable Cell Line-CHO TRPM4 Human Epithelial-like INQUIRY
ACC-RI0194 Human TRPC6 Stable Cell Line-HEK293 TRPC6 Human Epithelial INQUIRY
ACC-RI0193 Human TRPC1 Stable Cell Line-HEK293 TRPC1 Human Epithelial INQUIRY
First « 1 2 » Last
For research use only.

Related Section

  • Sodium Channels
  • Calcium Channels
  • Potassium Channels
  • Chloride Channels
  • ATP gated P2X Channels
  • ASICs
  • Nicotinic Acetylcholine Receptors
  • Ionotropic Glutamate-gated Receptors
  • GABAa Receptors
  • Glycine Receptors
  • 5-HT Receptors3
  • Cystic Fibrosis Transmembrane Conductance Regulators (CFTR)
  • Other Ion Channels

Inquiry


Subscribe
  • Links
  • Sodium Channels
  • Calcium Channels
  • Potassium Channels
  • Chloride Channels
  • TRP Channels
  • ATP gated P2X Channels
  • ASICs
  • USA
  • Europe

Copyright © 2025 Creative Bioarray. All rights reserved.